Nature's Medicines

While surfing for Naturally occuring substances to block inducible Ntric Oxide Synthase which runs rampant in some bacterial meningits

Interferon-γ-Induced Nitric Oxide Synthase-2 Contributes to Blood/Brain Barrier Dysfunction and Acute Mortality in Experimental Streptococcus pneumoniae Meningitis
Yau Belinda, Mitchell Andrew J., Too Lay Khoon, Ball Helen J., and Hunt Nicholas H.
Journal of Interferon & Cytokine Research.

 and causes death,  the following list was discovered:

A. debilis, Caesalpinia sappan, Curcuma longa, C. zedoaria, Daphne genkwa and Morus alba were also considered as potential inhibitors of iNOS activity (>70% inhibition at the test concentration of 10 micro g/ml).

from the following article:

J Ethnopharmacol. 2002 Nov;83(1-2):153-9.

Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells.

Hong CH¹, Hur SK, Oh OJ, Kim SS, Nam KA, Lee SK.

 

of which this plant was identified in general as a regulator from Wikipedia

Caesalpinia sappan is a species of flowering tree in the legume family, Fabaceae, that is native to Southeast Asia and the Malay archipelago. Common names include Sappanwood, Sapanwood, Patanga-Chekke Sappanga (Kannada), Pathimukham (Malayalam), and Suō (Japanese). Sappanwood belongs to the same genus as Brazilwood (C. echinata), and was originally called "brezel wood" in Europe.
Disease : Twig dieback (Lasiodiplodia theobromae)^[2]
This plant has many uses. It possesses medicinal abilities as an antibacterial and for its anticoagulant properties. It also produces a valued type of reddish dye called brazilin, used for dyeing fabric as well as making red paints and inks. Slivers of heartwood are used for making herbal drinking water in Kerala. Heartwood also contains juglone (5-hydroxy-1,4-naphthoquinone), also an active antimicrobial principle.^[3] Homoisoflavonoids (sappanol, episappanol, 3'-deoxysappanol, 3'-O-methylsappanol, 3'-O-methylepisappanol^[4] and sappanone A^[5]) can also be found in C. sappan.
The wood is somewhat lighter in color than Brazilwood and its other allies, but the same tinctorial principle appears to be common to all. Sappanwood was a major trade good during the 17th century, when it was exported from Southeast Asian nations (especially Siam) aboard red seal ships to Japan.

 

As a footnote it is interesting to note that some references to this "plant" listed it as poisonous so one must consult a trained naturalist/botanist to ingest this and it will show up on toxicology screens.

 

 

 

 

ANTICONVULSANT FROM WOOD

http://link.springer.com/article/10.1007/BF02975445#page-1