While surfing for Naturally occuring substances to block inducible Ntric Oxide Synthase which runs rampant in some bacterial meningits
Interferon-γ-Induced Nitric Oxide Synthase-2 Contributes to Blood/Brain Barrier Dysfunction and Acute Mortality in Experimental
Streptococcus pneumoniae Meningitis
Yau Belinda, Mitchell Andrew J., Too Lay Khoon, Ball Helen J., and Hunt Nicholas H.
Journal of Interferon & Cytokine Research.
and causes death, the following list was discovered:
A. debilis,
Caesalpinia sappan, Curcuma longa, C. zedoaria, Daphne genkwa and Morus alba were also considered as potential inhibitors of iNOS activity (>70% inhibition at the test concentration of 10 micro g/ml).
from the following article:
Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells.
of which this plant was identified in general as a regulator from Wikipedia
Caesalpinia sappan is a species of
flowering tree in the
legume family,
Fabaceae, that is native to
Southeast Asia and the
Malay archipelago. Common names include
Sappanwood,
Sapanwood,
Patanga-Chekke Sappanga (
Kannada),
Pathimukham (
Malayalam), and
Suō (
Japanese). Sappanwood belongs to the same genus as
Brazilwood (
C. echinata), and was originally called "brezel wood" in Europe.
Disease : Twig dieback (
Lasiodiplodia theobromae)
[2]
This plant has many uses. It possesses medicinal abilities as an
antibacterial and for its
anticoagulant properties. It also produces a valued type of reddish
dye called
brazilin, used for dyeing fabric as well as making red paints and inks. Slivers of heartwood are used for making herbal drinking water in
Kerala. Heartwood also contains
juglone (5-hydroxy-1,4-naphthoquinone), also an active antimicrobial principle.
[3] Homoisoflavonoids (
sappanol, episappanol, 3'-deoxysappanol, 3'-O-methylsappanol, 3'-O-methylepisappanol
[4] and
sappanone A[5]) can also be found in
C. sappan.
The
wood is somewhat lighter in color than Brazilwood and its other allies, but the same tinctorial principle appears to be common to all. Sappanwood was a major trade good during the 17th century, when it was exported from Southeast Asian nations (especially
Siam) aboard
red seal ships to
Japan.
As a footnote it is interesting to note that some references to this "plant" listed it as poisonous so one must consult a trained naturalist/botanist to ingest this and it will show up on toxicology screens.
ANTICONVULSANT FROM WOOD
